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1 August 2018

Shire plc

("Shire" or the "Company")

Rule 2.9 Announcement

In accordance with Rule 2.9 of the City Code on Takeovers and Mergers, the Company confirms that, as at the close of business on 31 July 2018, being the last business day prior to the date of this announcement, it had 921,756,420 ordinary shares of 5 pence each in issue and admitted to trading on the main market of the London Stock Exchange. Shire holds 7,357,283 ordinary shares in treasury. Accordingly, the total number of voting rights in Shire is 914,399,137. The International Securities Identification Number ("

ISIN

") for Shire`s ordinary shares is JE00B2QKY057.

Shire has an American Depositary Share ("

ADS

") programme for which Citibank, N.A. acts as depositary. One ADS represents three ordinary shares of 5 pence each, with ISIN US82481R1068. The ADSs trade on the NASDAQ Global Select Market.

Enquiries:

Shire plc

Christoph Brackmann (Investor Relations) +41 41 288 4129

Sun Kim (Investor Relations) +1 617 588 8175

Katie Joyce (Media) +1 781 482 2779

This announcement is distributed by Nasdaq Corporate Solutions on behalf of Nasdaq Corporate Solutions clients.

The issuer of this announcement warrants that they are solely responsible for the content, accuracy and originality of the information contained therein.

Source: Shire plc via GlobeNewswire

HUG#2208358

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